Vaccinia Virus – A Versatile Mammalian Expression Vector

• Virus best known for it’s use as a vaccine for Smallpox, discovered by Edward Jenner in 1798
• Double stranded DNA virus with large cloning capacity
• Envelope is derived from the Trans-Golgi Network membrane
• Recombinant proteins undergo normal post-translational modifications and trafficking and are subject to mammalian cell QC mechanisms

Vaccinex has developed propriety technology to:

• Efficiently create large cDNA libraries in  Vaccinia Virus for mammalian expression
• Fusion proteins to allow for direct incorporation of either IgG or multipass membrane proteins into the Vaccinia Virus membrane